Identification, Quantification, And Characterization Of Morphological Patterns in the Mid-thigh

Thigh MRI Quantification

The quantification of regional tissue components and their longitudinal changes is a key parameter in epidemiological studies, because it may help to monitor changes in body composition and function. The purpose of this project is to develop an automated method to delineate and quantify the main tissue components in the middle thigh anatomical site from volumetric MRI data.

Our objective is to delineate the main tissues in mid-thigh, namely subcutaneous fat, inter-muscular fat, muscle, cortical and endosteal bone components. The subcutaneous fat is segmentation using active contours, and the inter-muscular fat is separated from muscle using clustering methods. Finally the bone is identified by shape recognition. The quantification of each tissue involves computation of volume, average area, and first and second order intensity statistics. The method was validated versus reference quantification on CT imaging data of the same subjects produced by a semi-manual workflow.

Fig. 1: Overview of the thigh quantification method.

Fig. 2: Performance evaluation against a semi-manual CT-based quantification.

  1. Makrogiannis SSerai SFishbein KWSchreiber CFerrucci LSpencer RG.  2012.  Automated quantification of muscle and fat in the thigh from water-, fat-, and nonsuppressed MR images.. J Magn Reson Imaging. 35:1152–1161.